CBD

CBD Pain Treatment

Cannabidiol (CBD) is a naturally occurring cannabinoid constituent of cannabis, which is either derived from marijuana or industrial hemp. It was discovered in 1940 and initially thought not to be medically active. Cannabidiol can be taken into the body in multiple different ways, including by inhalation of cannabis smoke or vapor, as an aerosol spray into the cheek, and by mouth. It may be supplied as an oil containing only CBD as the active ingredient (no added THC or terpenes), a full-plant CBD-dominant hemp extract oil, capsules, dried cannabis, a prescription liquid solution, or a topical cream.

Cannabidiol (CBD) is one of more than 80 active cannabinoid chemicals in the marijuana plant.1 Unlike the main psychoactive cannabinoid in marijuana, tetrahydrocannabinol (THC), CBD does not produce euphoria or intoxication.2,3,4 CBD can be derived from marijuana or hemp also known as industrial hemp, which contains little to no THC. Cannabinoids have their effect mainly by interacting with specific receptors on cells in the brain and body: the CB1 receptor, found on neurons and glial cells in various parts of the brain, and the CB2 receptor, found mainly in the body’s immune system. The euphoric effects of THC are caused by its activation of CB1 receptors. CBD has a very low affinity for these receptors (100 fold less than THC), and when it binds it produces little to no effect. Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor5. There is also growing evidence that CBD acts on other brain signaling systems and that these actions may be important contributors to its therapeutic effects.4